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血小板相关参数在射血分数保留型心力衰竭临床应用中的研究进展

刘潇, 张银花

摘要

射血分数保留型心力衰竭（HFpEF）约占全球心衰病例的一半，其特征是症状负担显著、预后不良及有限的治疗手段，且该病临床辅助检查特征不明显，在诊治过程中易被忽视。其病理生理机制不仅限于左心室，还涉及血管、心肌、代谢和炎症通路，这些因素与通路共同作用，最终导致舒张功能障碍及心肌重塑。近年来，研究显示血小板相关参数，如血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）、血小板压积（PCT）等在HFpEF的病情评估与预后预测中有一定的作用。HFpEF的病理生理及其临床症状以炎症为特征，而血小板是炎症反应的重要参与者。本文总结了血小板相关参数在HFpEF中的临床应用进展。

关键词

射血分数保留型心力衰竭；血小板；炎症

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参考

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