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特发性肺纤维化分子生物标志物的研究进展

赵 佳莹, 俞 昌赫

摘要

特发性肺纤维化(Idiopathic pulmonary fibrosis,IPF)是一种病因不明、预后差的慢性进行性肺纤维化疾病,涉及上皮-间质转化、氧化应激、炎症及纤维化重塑等病理过程。临床急需用于诊断、预后及风险评估的生物标志物,以实现早期干预并为新药研发提供靶点。本文综述多种生物标志物在
IPF 中的临床价值,并展望多技术融合与标准化的发展方向。

关键词

特发性肺纤维化 分子生物学标志物 炎症因子 细胞转导

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参考

[1]王佳,支政,王杰鹏,等.特发性肺纤维化发病机制研究[J].临床误诊误治,2025,38(17):105-110.

[2]Richeldi L, Collard H R, Jones M G. Idiopathic pulmonary fibrosis[J]. The Lancet, 2017, 389(10082): 1941-1952.

[3]King Jr T E, Bradford W Z, Castro-Bernardini S, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis[J]. New England journal of medicine, 2014, 370(22): 2083-2092.

[4]Schutyser E, Richmond A, Van Damme J. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes[J]. Journal of leukocyte biology, 2005, 78(1): 14-26.

[5]Höhne K, Wagenknecht A, Maier C, et al. Pro-fibrotic effects of CCL18 on human lung fibroblasts are mediated via CCR6[J]. Cells, 2024, 13(3): 238.

[6]Zhu J, Jiang Q, Gao S, et al. IL20Rb aggravates pulmonary fibrosis through enhancing bone marrow derived profibrotic macrophage activation[J]. Pharmacological Research, 2024, 203: 107178.

[7]Calver J F, Parmar N R, Harris G, et al. Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis[J]. Journal of Biological Chemistry, 2024, 300(6): 107300.

[8]Liao H Y, Da C M, Liao B, et al. Roles of matrix metalloproteinase-7 (MMP-7) in cancer[J]. Clinical biochemistry, 2021, 92: 9-18.

[9]Wakamatsu K, Nagata N, Kumazoe H, et al. Prognostic value of serial serum KL-6 measurements in patients with idiopathic pulmonary fibrosis[J]. Respiratory investigation, 2017, 55(1): 16-23.

[10]Wang K, Ju Q, Cao J, et al. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis: A systematic review and meta-analysis[J]. Medicine, 2017, 96(23): e7083.

[11]Lian N, Jin H, Zhu W, et al. Inhibition of glutamine transporter ASCT2 mitigates bleomycin-induced pulmonary fibrosis in mice[J]. Acta Histochemica, 2022, 124(8): 151961.

[12]Ahangari F, Price N L, Malik S, et al. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis[J]. JCI insight, 2023, 8(4): e158100.

[13]Peng D, Fu M, Wang M, et al. Targeting TGF-β signal transduction for fibrosis and cancer therapy[J]. Molecular cancer, 2022, 21(1): 104.


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