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奥赛立定联合环泊酚在 ERCP 中的应用研究进展

张 琦, 南 勇善

摘要

内镜逆行胰胆管造影(ERCP)作为消化内镜领域中技术难度最高、操作风险最大的诊疗技术,对镇静麻醉提出了特殊要求。理想的镇静方案需在保证操作安全完成的同时,最大限度减少心肺并发症。环泊酚作为新型γ-氨基丁酸A型受体激动剂,具有起效快、恢复迅速、循环呼吸抑制轻微等药理特性;奥赛立定作为选择性G蛋白偏向性μ阿片受体激动剂,可在提供强效镇痛的同时减少传统阿片类药物相关的呼吸抑制和恶心呕吐。本文系统综述了两种药物联合应用于ERCP镇静麻醉的理论基础、临床研究进展及未来研究方向,以期为优化ERCP围术期管理提供参考。

关键词

奥赛立定;环泊酚;ERCP

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参考

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