Nidogen-2 基因多态性与 2 型糖尿病合并肥胖易感性的研究 进展
摘要
Nidogen-2基因多态性与2型糖尿病（T2D）合并肥胖易感性的研究进展，涵盖了其分子结构特征、遗传调控机制、以及
在葡萄糖稳态和能量代谢中的生物学功能。特别聚焦于最新发现的Nidogen-2在调节胰岛素敏感性、抑制胰高血糖素分
泌及促进脂肪细胞分化等方面的作用，分析了其基因多态性如何通过影响这些生理过程进而导致T2D和肥胖的发生发
展。通过对现有文献的全面梳理，本文旨在为T2D合并肥胖的遗传机制研究提供新视角，并为未来个体化防治策略开发
提供理论依据。
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