开放期刊系统

乳腺癌的发病机制及临床治疗的研究进展

季 天培, 王 振常

摘要

乳腺癌作为全球女性健康的第二大威胁,其研究进展备受瞩目。本文深入探讨乳腺癌发病机制,涵盖遗传因素、
基因突变、激素水平及不良生活方式等多方面,剖析其发病根源。同时,全面阐述乳腺癌治疗临床研究新进展,涉及手术、
放疗、化疗及内分泌治疗等,旨在为临床治疗决策提供科学依据,助力改善患者预后,延长生存期,提高生活质量。

关键词

乳腺癌;发病机制;治疗;进展

全文:

PDF

参考

[1] 全球疾病负担癌症协作组 . 1990 年至 2015 年全球、

区域和国家 32 种癌症组的癌症发病率、死亡率、寿命损失

年数、残疾年数和残疾调整生命年数 . JAMA Oncol. 2017 年

4 月 1 日 ;3(4):524-548.

[2] Möller S, Mucci LA, Harris JR, Scheike T, Holst K,

Halekoh U, Adami HO, Czene K, Christensen K, Holm NV,

Pukkala E, Skytthe A, Kaprio J, Hjelmborg JB. The Heritability of

Breast Cancer among Women in the Nordic Twin Study of Cancer.

Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):145-50. doi:

10.1158/1055-9965.EPI-15-0913.

[3] Sampson JN, Wheeler WA, Yeager M, et al. Analysis

of Heritability and Shared Heritability Based on Genome-Wide

Association Studies for Thirteen Cancer Types. J Natl Cancer Inst.

2015 Oct 12;107(12):djv279. doi: 10.1093/jnci/djv279. Erratum

in: J Natl Cancer Inst. 2016 Apr;108(4).

[4] Severi G, Southey MC, English DR, et al. Epigenome-wide

methylation in DNA from peripheral blood as a marker of risk for

breast cancer. Breast Cancer Res Treat. 2014 Dec;148(3):665-73.

[5] Yang Y, Wu L, Shu XO, et al. Genetically Predicted

Levels of DNA Methylation Biomarkers and Breast Cancer Risk:

Data From 228 951 Women of European Descent. J Natl Cancer

Inst. 2020 Mar 1;112(3):295-304.

[6] Allott EH, Hursting SD. Obesity and cancer: mechanistic

insights from transdisciplinary studies. Endocr Relat Cancer. 2015

Dec;22(6):R365-86.

[7] Zeitzer JM, Nouriani B, Rissling MB, Sledge GW, Kaplan

KA, Aasly L, Palesh O, Jo B, Neri E, Dhabhar FS, Spiegel D.

Aberrant nocturnal cortisol and disease progression in women with

breast cancer. Breast Cancer Res Treat. 2016 Jul;158(1):43-50.

[8] 乳腺癌激素因素协作组 . 绝经后激素治疗的类型和

时机与乳腺癌风险:全球流行病学证据的个体参与者荟萃分

析 . Lancet. 2019 年 9 月 28 日 ;394(10204):1159-1168.

[9] 北美更年期学会 . 北美更年期学会 2012 年激素治疗

立场声明 . 更年期 . 2012 年 3 月 ;19(3):257-71.

[10] Cottet V, Touvier M, Fournier A, Touillaud MS, Lafay L,

Clavel-Chapelon F, Boutron-Ruault MC. Postmenopausal breast

cancer risk and dietary patterns in the E3N-EPIC prospective

cohort study. Am J Epidemiol. 2009 Nov 15;170(10):1257-67.

[11] Castelló A, Pollán M, Buijsse B, Ruiz A, Casas AM,

Baena-Cañada JM, Lope V, Antolín S, Ramos M, Muñoz M,

Lluch A, de Juan-Ferré A, Jara C, Jimeno MA, Rosado P, Díaz

E, Guillem V, Carrasco E, Pérez-Gómez B, Vioque J, Boeing

H, Martín M; GEICAM researchers. Spanish Mediterranean diet

and other dietary patterns and breast cancer risk: case-control

EpiGEICAM study. Br J Cancer. 2014 Sep 23;111(7):1454-62.

[12] Hirko KA, Willett WC, Hankinson SE, Rosner BA, Beck

AH, Tamimi RM, Eliassen AH. Healthy dietary patterns and risk

of breast cancer by molecular subtype. Breast Cancer Res Treat.

2016 Feb;155(3):579-88.

[13] McTiernan A, Friedenreich CM, Katzmarzyk PT,

Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B,

Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy

KL; 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY

COMMITTEE*. Physical Activity in Cancer Prevention and

Survival: A Systematic Review. Med Sci Sports Exerc. 2019

Jun;51(6):1252-1261.

[14] Ibrahim EM, Al-Homaidh A. Physical activity and

survival after breast cancer diagnosis: meta-analysis of published

studies. Med Oncol. 2011 Sep;28(3):753-65.

[15] Stick LB, Yu J, Maraldo MV, Aznar MC, Pedersen AN,

Bentzen SM, Vogelius IR. Joint Estimation of Cardiac Toxicity

and Recurrence Risks After Comprehensive Nodal Photon Versus

Proton Therapy for Breast Cancer. Int J Radiat Oncol Biol Phys.

2017 Mar 15;97(4):754-761.

[16] Tanaka S, Iwamoto M, Kimura K, Matsunami N,

Morishima H, Yoshidome K, Nomura T, Morimoto T, Yamamoto

D, Tsubota Y, Kobayashi T, Uchiyama K. Phase II Study of

Neoadjuvant Anthracycline-Based Regimens Combined With

Nanoparticle Albumin-Bound Paclitaxel and Trastuzumab for

Human Epidermal Growth Factor Receptor 2-Positive Operable

Breast Cancer. Clin Breast Cancer. 2015 Jun;15(3):191-6.

[17] Wapnir IL, Anderson SJ, Mamounas EP, Geyer CE Jr,

Jeong JH, Tan-Chiu E, Fisher B, Wolmark N. Prognosis after

ipsilateral breast tumor recurrence and locoregional recurrences

in five National Surgical Adjuvant Breast and Bowel Project node-

positive adjuvant breast cancer trials. J Clin Oncol. 2006 May

1;24(13):2028-37.

[18] Donker M, van Tienhoven G, Straver ME, Meijnen P, van

de Velde CJ, Mansel RE, Cataliotti L, Westenberg AH, Klinkenbijl

JH, Orzalesi L, Bouma WH, van der Mijle HC, Nieuwenhuijzen

GA, Veltkamp SC, Slaets L, Duez NJ, de Graaf PW, van Dalen T,

Marinelli A, Rijna H, Snoj M, Bundred NJ, Merkus JW, Belkacemi

Y, Petignat P, Schinagl DA, Coens C, Messina CG, Bogaerts J,

Rutgers EJ. Radiotherapy or surgery of the axilla after a positive

sentinel node in breast cancer (EORTC 10981-22023 AMAROS):

a randomised, multicentre, open-label, phase 3 non-inferiority

trial. Lancet Oncol. 2014 Nov;15(12):1303-10.

[19] Early Breast Cancer Trialists’ Collaborative Group

(EBCTCG), Davies C, Godwin J, Gray R, Clarke M, Cutter D,

Darby S, McGale P, Pan HC, Taylor C, Wang YC, Dowsett M,

Ingle J, Peto R. Relevance of breast cancer hormone receptors

and other factors to the efficacy of adjuvant tamoxifen: patient-

level meta-analysis of randomised trials. Lancet. 2011 Aug

27;378(9793):771-84.

[20] Bidard FC, Kaklamani VG, Neven P, Streich G, Montero

AJ, Forget F, Mouret-Reynier MA, Sohn JH, Taylor D, Harnden

KK, Khong H, Kocsis J, Dalenc F, Dillon PM, Babu S, Waters S,

Deleu I, García Sáenz JA, Bria E, Cazzaniga M, Lu J, Aftimos P,

Cortés J, Liu S, Tonini G, Laurent D, Habboubi N, Conlan MG,

Bardia A. Elacestrant (oral selective estrogen receptor degrader)

Versus Standard Endocrine Therapy for Estrogen Receptor-

Positive, Human Epidermal Growth Factor Receptor 2-Negative

Advanced Breast Cancer: Results From the Randomized Phase III

EMERALD Trial. J Clin Oncol. 2022 Oct 1;40(28):3246-3256.


(0 摘要 Views, 0 PDF Downloads)

Refbacks

  • 当前没有refback。