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HIV 感染并发 / 合并的特应性皮炎:发病机制与治疗进展

罗  清*

摘要

特应性皮炎(atopic dermatitis, AD)为 HIV 感染常见的并发 / 合并症之一。在作为 HIV 感染并发症的情况下,其
发病机制主要涉及免疫异常、微生物群紊乱及皮肤屏障功能障碍等。HIV 感染者轻度 AD 的治疗与单纯 AD 无明显不同,
然而由于担心在免疫缺陷状态下使用免疫抑制剂或免疫调节剂造成不良后果,HIV 感染者伴发中重度 AD 的治疗需要更多
地探索使用新疗法进行干预,方法主要包括抑制 Th2 细胞因子 - 受体 -JAK-STAT 通路信号传导及改善微生物群等。

关键词

艾滋病病毒感染;特应性皮炎;发病机制;治疗进展

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参考

[1] 中华医学会感染病学分会艾滋病丙型肝炎学组 , 中

国疾病预防控制中心 . 中国艾滋病诊疗指南 (2021 年版 )[J].

协和医学杂志 ,2022,13(2):203-226.

[2] 中华医学会皮肤性病学分会免疫学组 , 特应性皮炎

协作研究中心 . 中国特应性皮炎诊疗指南 (2020 版 )[J]. 中华

皮肤科杂志 ,2020,53(2):81-88.

[3]Garg T, Sanke S. Inflammatory dermatoses in human

immunodeficiency virus[J]. Indian J Sex Transm Dis AIDS.

2017;38(2):113-120.

[4]Syrbe U,Siveke J, Hamann A.Th1/Th2 subsets: distinct

differences in homing and chemokine receptor expression?[J].

Springer Semin Immunopathol. 1999;21(3):263-285.

[5]Orlova-Fink N, Chowdhury F.Z, Xiaoming S, et al.

Preferential susceptibility of Th9 and Th2 CD4 T cells to X4-

tropic HIV-1 infection[J]. AIDS. 2017;31:2211.

[6]Gunathilake R, Schmuth M, Scharschmidt TC, et al.

Epidermal barrier dysfunction in non-atopic HIV: evidence for

an “inside-to-outside” pathogenesis[J].J Invest Dermatol.

2010;130(4):1185-1188.

[7]Dubin C, Del Duca E, Guttman-Yassky E. The IL-4, IL-

13 and IL-31 pathways in atopic dermatitis[J]. Expert Rev Clin

Immunol. 2021;17(8):835-852.

[8]Furue M, Yamamura K, Kido-Nakahara M,etal.Emerging

role of interleukin-31 and interleukin-31 receptorin pruritus in

atopic dermatitis[J]. Allergy. 2018 Jan;73(1):29–36.

[9]Kiehl P, Falkenberg K, Vogelbruch M, et al. Tissue

eosinophilia in acute and chronic atopic dermatitis: a

morphometric approach using quantitative image analysis of

immunostaining[J]. Br J Dermatol. 2001;145(5):720-729.

[10]Edslev SM,AgnerT,AndersenPS.SkinMicrobiome

inAtopic Dermatitis[J].Acta DermVenereol.2020;100(12):a

dv00164

[11]Möbus L, Rodriguez E, Harder I, et al. Elevated NK-

cell transcriptional signature and dysbalance of resting and

activated NK cells in atopic dermatitis[J]. J Allergy Clin Immunol.

2021;147(5):1959-1965.e2.

[12]Müller M, Wandel S, Colebunders R,etal.Immune

reconstitution inflammatory syndrome in patients starting

antiretroviral therapy for HIV infection: a systematic review and

meta-analysis[J]. Lancet Infect Dis. 2010;10(4):251-261.

[13] Yu DM, Zhao J, Lee EE, et al. GLUT3 promotes

macrophage signaling and function via RAS-mediated endocytosis

in atopic dermatitis and wound healing[J]. J Clin Invest.

2023;133(21):e170706.

[14] Novak N, Koch S, Allam JP, et al. Dendritic cells:

bridging innate and adaptive immunity in atopic dermatitis[J]. J

Allergy Clin Immunol. 2010;125(1):50-59.

[15] Savolainen J, Kosonen J, Kortekangas-Savolainen

O, et al. HLA-DR-dependent increased mannan-induced

lymphoproliferative response in atopic eczema dermatitis

syndrome[J]. Allergy. 2003;58(1):72-77.

[16] 曹婷 , 邹颖 . 特应性皮炎与皮肤微生态研究进展 [J].

实用皮肤病学杂志 ,2020,13(3).

[17] Su H, Luo Y, Sun J, et al. Transglutaminase 3 Promotes

Skin Inflammation in Atopic Dermatitis by Activating Monocyte-

Derived Dendritic Cells via DC-SIGN[J]. J Invest Dermatol.

2020;140(2):370-379.e8.

[18] K u r n i a d i I , H e n d r a W i j a y a W , T i m o t i u s

KH.Malasseziavirulence factors and their role in dermatological

d i s o r d e r s [ J ] . A c t a D e r m a t o v e n e r o l A l p P a n n o n i c a

Adriat.2022;31(2):65-70.

[19] Lu W, Feng Y, Jing F, et al. Association Between Gut

Microbiota and CD4 Recovery in HIV-1 Infected Patients[J].

Front Microbiol. 2018;9:1451.

[20]JorgensenJ,Bach-MortensenN,KochC,et al.Bacteria

and endotoxin induce release of basophil histamine in

patients with atopic dermatitis. In vitro experiments

with S.aureus,teichoicacid,E.coli and E.coliLPS[J].

Allergy.1987;42(5):395-397.

[21]Guttman-Yassky E, Irvine AD, Brunner PM,etal.The role

of Janus kinase signaling in the pathology of atopic dermatitis[J].

JAllergy Clin Immunol.2023;152(6):1394-1404.

[22]Frazier W,Bhardwaj N.AtopicDermatitis:Diagnosisand

Treatment[J].Am Fam Physician. 2020;101(10):590-598.

[23]GadeA,Ghani H,Patel P,etal.Dupilumab[OL].

In:StatPearls.TreasureIsland(FL):StatPearls Publishing; February

28,2024.

[24] Simpson EL, Schlievert PM, Yoshida T, et al. Rapid

reduction in Staphylococcus aureus in atopic dermatitis subjects

following dupilumab treatment[J]. J Allergy Clin Immunol.

2023;152(5):1179-1195.

[25] Patella V, Florio G, Petraroli A, et al. HIV-1 gp120

induces IL-4 and IL-13 release from human Fc epsilon RI+ cells

through interaction with the VH3 region of IgE[J]. J Immunol.

2000;164(2):589-595.

[26]Nakashima C, Yanagihara S, Otsuka A. Innovation in the

treatment of atopic dermatitis: Emerging topical and oral Janus

kinase inhibitors[J]. Allergol Int. 2022;71(1):40-46.


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